Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27905445 | 0.84 | ALOX5 (0.36) | KDM4EGLAPOLBMAPT | |
| SCHEMBL2723798 | 0.81 | HSD17B10 (0.33) | KDM4EGLAPOLBMAPT | |
| SCHEMBL2711904 | 0.78 | CRHBP (0.32) | KDM4EMAPT | |
| SCHEMBL9939459 | 0.74 | CYP3A4 (0.36) | — | |
| SCHEMBL29948393 | 0.72 | IDO1 (0.36) | POLBMAPT | |
| SCHEMBL156162 | 0.72 | IDO1 (0.36) | POLBMAPT | |
| SCHEMBL17753601 | 0.72 | — | — | |
| SCHEMBL1711711 | 0.71 | KDM4E (0.42) | KDM4EGLAPOLBMAPTMAP2K3 | |
| SCHEMBL12374084 | 0.70 | ADORA2A (0.44) | KDM4EGLAMAPT | |
| SCHEMBL18498761 | 0.70 | GAA (0.33) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632923-A1 | QUINAZOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |