Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | IL1B | P01584 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30932818 | 1.00 | NLRP3 (0.62) | NLRP3KCNH2IL1BMAPTTNF | |
| SCHEMBL27224470 | 0.94 | NLRP3 (0.59) | NLRP3KCNH2IL1BMAPTTNF | |
| SCHEMBL30932875 | 0.94 | NLRP3 (0.59) | NLRP3KCNH2IL1BMAPTTNF | |
| SCHEMBL30157129 | 0.89 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNFCNR1 | |
| SCHEMBL27224429 | 0.89 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNFCNR1 | |
| SCHEMBL30157075 | 0.85 | NLRP3 (0.72) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224458 | 0.85 | NLRP3 (0.72) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30157058 | 0.84 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224451 | 0.84 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30156937 | 0.80 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4375274-A1 | ANNULATED PYRIDAZINE COMPOUND | Nico Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |