Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | IL1B | P01584 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30932875 | 1.00 | NLRP3 (0.59) | NLRP3KCNH2IL1BMAPTSCN9A | |
| SCHEMBL27224457 | 0.94 | NLRP3 (0.62) | NLRP3KCNH2IL1BMAPTTNF | |
| SCHEMBL30932818 | 0.94 | NLRP3 (0.62) | NLRP3KCNH2IL1BMAPTTNF | |
| SCHEMBL30157058 | 0.90 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224451 | 0.90 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224429 | 0.84 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30157129 | 0.84 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30156937 | 0.84 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224407 | 0.84 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30157080 | 0.83 | NLRP3 (0.62) | NLRP3KCNH2IL1BSCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4375274-A1 | ANNULATED PYRIDAZINE COMPOUND | Nico Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |