Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28237888 | 0.84 | ALPL (0.42) | — | |
| SCHEMBL5611770 | 0.82 | SCN9A (0.40) | SCN9APLA2G10 | |
| SCHEMBL30341948 | 0.77 | NNMT (0.47) | PLA2G10MAPK1KMT2AKDM4EGAA | |
| SCHEMBL20521318 | 0.76 | PLA2G10 (0.38) | SCN9APLA2G10MAPK1KMT2AGAA | |
| SCHEMBL27028221 | 0.74 | SCN9A (0.60) | SCN9AGAA | |
| SCHEMBL2790797 | 0.73 | PLA2G10 (0.41) | SCN9APLA2G10KMT2AMAP2K4USP7 | |
| SCHEMBL17351884 | 0.72 | NPC1 (0.31) | SCN9AMAPK1CYP2C9GAA | |
| Hydrochloric Acid SCHEMBL29825482 | 0.71 | PLA2G10 (0.40) | SCN9APLA2G10KMT2AMAP2K4USP7 | |
| Hydrochloric Acid SCHEMBL31067680 | 0.71 | PLA2G10 (0.40) | SCN9APLA2G10KMT2AMAP2K4USP7 | |
| SCHEMBL1827221 | 0.71 | MAPK1 (0.47) | SCN9APLA2G10MAPK1USP7CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | Grünenthal GmbH (DE) | 2024-06-04 | — | — | US | claimed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | claimed |
| US-11999699-B2 | Substituted pyrazole amides | Grünenthal GmbH (DE) | 2024-06-04 | — | — | US | disclosed |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999699-B2 | Substituted pyrazole amides | SCN8A, SCN1A, SCN7A | SCN9A 9/4885PLA2G10 2898/4885MAPK1 1196/4885 |
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | SCN9A 9/4885PLA2G10 2898/4885MAPK1 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.