Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27316074 | 0.82 | MAPK1 (0.47) | NNMTMAPK1SIRT6POLBLMNA | |
| SCHEMBL28154526 | 0.82 | ALPL (0.54) | MAPK1LMNATDP1ALPLCA9 | |
| SCHEMBL30107039 | 0.81 | MAPK1 (0.70) | MAPK1POLBLMNAMAPTGAA | |
| SCHEMBL27232998 | 0.77 | SCN9A (0.49) | MAPK1PLA2G10GAAKMT2AKDM4E | |
| SCHEMBL20521318 | 0.77 | PLA2G10 (0.38) | MAPK1SIRT6PLA2G10LMNAMAPT | |
| SCHEMBL1827221 | 0.75 | MAPK1 (0.47) | MAPK1PLA2G10LMNAALPLHCAR2 | |
| SCHEMBL27256360 | 0.75 | RAB9A (0.59) | MAPK1LMNAMAPTMEN1GAA | |
| SCHEMBL24276956 | 0.74 | — | — | |
| SCHEMBL1374372 | 0.74 | — | — | |
| SCHEMBL5599765 | 0.72 | HCAR2 (0.53) | MAPK1PLA2G10HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253384-B | Preparation and application of 3-isoxazole methoxy pyrazole-5-amide containing substituted phenyl isoxazole unit | 南通大学 | 2023-04-07 | — | — | CN | claimed |
| CN-111253384-B | Preparation and application of 3-isoxazole methoxy pyrazole-5-amide containing substituted phenyl isoxazole unit | 南通大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-111253384-B | Preparation and application of 3-isoxazole methoxy pyrazole-5-amide containing substituted phenyl isoxazole unit | 南通大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-111253384-B | Preparation and application of 3-isoxazole methoxy pyrazole-5-amide containing substituted phenyl isoxazole unit | 南通大学 | 2023-04-07 | — | — | CN | disclosed |