Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGB | P11216 | 7/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28444663 | 0.87 | CA12 (0.44) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL734876 | 0.87 | CA12 (0.44) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL28448246 | 0.87 | CA12 (0.44) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL28448523 | 0.87 | CA12 (0.44) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL9346601 | 0.86 | CA12 (0.42) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL6753925 | 0.80 | PYGB (0.33) | PYGB | |
| SCHEMBL6743838 | 0.79 | LGALS3 (0.31) | — | |
| SCHEMBL18376340 | 0.73 | PYGB (0.49) | PYGBCA12CA1CA2CA9 | |
| SCHEMBL699573 | 0.73 | IGF2R (0.40) | — | |
| SCHEMBL29240455 | 0.72 | FOLH1 (0.40) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230315-A1 | ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN | Amgen Inc. (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092101-A1 | ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN | AMGEN INC. (US) | 2016-06-16 | — | — | WO | disclosed |
| EP-2632951-A2 | DKK1 ANTIBODIES AND METHODS OF USE | Amgen Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058393-A2 | DKK1 ANTIBODIES AND METHODS OF USE | AMGEN INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| US-5788967-A | WOUND HEALING AGENTS FROM SALIVARY PROTEIN LUMICARMINE | HENKIN R I (US) | 1998-08-04 | — | — | US | disclosed |