Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919280 | 0.85 | HTR2C (0.60) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL24324093 | 0.83 | PDE10A (0.46) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL24922389 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4ECYP1A2HSD17B10MEN1 | |
| SCHEMBL3267269 | 0.77 | TAAR1 (0.54) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL25189276 | 0.77 | HTR3E (0.58) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL13039373 | 0.74 | HTR2C (0.64) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL19581644 | 0.74 | HTR2C (0.64) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| Mk-212 SCHEMBL29389957 | 0.74 | HTR2A (1.00) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL6014714 | 0.74 | HTR2C (0.64) | HTR2CHTR2AHTR1AALDH1A1KDM4E | |
| SCHEMBL1026934 | 0.74 | HTR2C (0.64) | HTR2CHTR2AHTR1AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-08-29 | — | — | US | disclosed |
| EP-2629616-A2 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054366-A2 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | PDE10A, PDE12, PDE4A | HTR2C 136/4885HTR2A 124/4885HTR1A 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.