SCHEMBL27243743

SCHEMBL27243743

COc1ccc(CN(C)C(=O)c2ncc3[nH]nc(-c4ccc(Cl)cc4)c3n2)cc1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAP4K1 Q92918 1/20 0.42
▸ HSP90AA1 P07900 1/20 0.41
▸ MAPK6 Q16659 1/20 0.41
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ CXCR3 P49682 1/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ PTGDR2 Q9Y5Y4 2/20 0.40
▸ MAPK1 P28482 1/20 0.39
▸ VNN1 O95497 1/20 0.38
▸ GPBAR1 Q8TDU6 1/20 0.38
▸ TSPO P30536 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.38
▸ HSD17B2 P37059 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27243915 0.77 MAP2K4 (0.52) MAP4K1MAPK6KMT2ASMN1; SMN2ALDH1A1
SCHEMBL30881476 0.77 MAP2K4 (0.52) MAP4K1MAPK6KMT2ASMN1; SMN2ALDH1A1
SCHEMBL27243801 0.74 MAP2K4 (0.48) MAP4K1MAPK6MAPK1
SCHEMBL27254069 0.72 FGFR2 (0.48) MAP4K1SMN1; SMN2
SCHEMBL27243817 0.72 ALDH1A1 (0.35) HSP90AA1MEN1KMT2ACXCR3SMN1; SMN2
SCHEMBL30881409 0.72 ALDH1A1 (0.35) HSP90AA1MEN1KMT2ACXCR3SMN1; SMN2
SCHEMBL30881415 0.65 MEN1 (0.42) MEN1KMT2ASMN1; SMN2MAPTPTGDR2
SCHEMBL27244016 0.65 MEN1 (0.42) MEN1KMT2ASMN1; SMN2MAPTPTGDR2
SCHEMBL4336422 0.64 MAPK14 (0.45) HSP90AA1MEN1KMT2AMAPK1
SCHEMBL30881410 0.64 NR3C1 (0.43) HSP90AA1MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598923-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS The Regents of the University of California (US) 2025-08-13 — — EP disclosed
US-20240201205-A1 METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
WO-2024059845-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-03-21 — — WO disclosed
WO-2024059845-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-03-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS MAPT, HTT, PSEN1 MAP4K1 3813/4885HSP90AA1 2090/4885MAPK6 3542/4885
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS PRNP, PSEN1, SNCA MAP4K1 2956/4885HSP90AA1 555/4885MAPK6 2745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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