SCHEMBL2724733

SCHEMBL2724733

CCc1cccc(-c2[c]c3ccccc3cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
CYP2A6 P11509 1/20 0.44
BCL2 P10415 1/20 0.39
IDO1 P14902 1/20 0.38
NISCH Q9Y2I1 1/20 0.37
NOTUM Q6P988 1/20 0.35
PTGS2 P35354 1/20 0.35
TP53 P04637 2/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
SIGMAR1 Q99720 5/20 0.33
DHFR P00374 1/20 0.33
GAA P10253 1/20 0.33
KDR P35968 1/20 0.32
TGFBR1 P36897 1/20 0.32
FGFR1 P11362 1/20 0.32
KIF11 P52732 1/20 0.31
MGLL Q99685 1/20 0.31
CYP2D6 P10635 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27802181 0.86 LOXL2 (0.41)
SCHEMBL4156055 0.79 CYP2A6 (0.39) CYP1A2CYP2A6TSHR
SCHEMBL3149855 0.78 MAOA (0.36) FGFR1MGLL
SCHEMBL5198605 0.76 TAAR1 (0.40) CYP1A2CYP2A6TP53GAATSHR
SCHEMBL11516832 0.76 MAOA (0.47) TP53TSHR
SCHEMBL79020 0.75 ALDH1A1 (0.35) CYP2A6TSHR
SCHEMBL27802178 0.75 CYP1A2 (0.46) CYP1A2CYP2A6TP53CYP2D6
SCHEMBL1719526 0.74 GSTP1 (0.44) CYP1A2NISCHTP53
SCHEMBL27683162 0.73 TAAR1 (0.48) CYP2A6TP53
SCHEMBL4216130 0.73 ESR1 (0.38) CYP1A2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2632420-A1 GLUTAMINE DERIVATIVES AS DEODORANTS Givaudan SA (CH) 2013-09-04 EP disclosed
WO-2012056014-A1 GLUTAMINE DERIVATIVES AS DEODORANTS GIVAUDAN SA (CH) 2012-05-03 WO disclosed