Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27253438 | 0.82 | KDM4E (0.51) | MAPK10MAPK8MAPK9HCAR3TP53 | |
| SCHEMBL27251805 | 0.79 | PCSK9 (0.44) | MAPK10MAPK8MAPK9MGAMGAA | |
| SCHEMBL31063901 | 0.79 | PCSK9 (0.44) | MAPK10MAPK8MAPK9MGAMGAA | |
| SCHEMBL4013746 | 0.78 | MKNK1 (0.53) | MAPK10MAPK8MAPK9TP53PDE10A | |
| SCHEMBL22242768 | 0.74 | HCAR3 (0.47) | MAPK10MAPK8MAPK9HCAR3TP53 | |
| SCHEMBL27253442 | 0.73 | ADORA3 (0.46) | MAPK10MAPK9HCAR3KDM4ELMNA | |
| SCHEMBL4176633 | 0.73 | KCNN2 (0.60) | MAPK10MAPK8MAPK9PDE10AGAA | |
| SCHEMBL27253443 | 0.73 | HCAR3 (0.45) | MAPK10HCAR3TP53KDM4ELMNA | |
| SCHEMBL14193418 | 0.72 | MAPK8 (0.79) | MAPK10MAPK8MAPK9 | |
| SCHEMBL27260448 | 0.72 | PIK3CA (0.44) | HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024062090-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-03-28 | — | — | WO | disclosed |