Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4176633 | 0.81 | KCNN2 (0.60) | MAPK8MAPK9MAPK10PDE10ACDC7 | |
| SCHEMBL14193418 | 0.78 | MAPK8 (0.79) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL27253441 | 0.78 | MAPK10 (0.46) | MAPK8MAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL14768385 | 0.74 | MAPK8 (0.62) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL4017740 | 0.74 | CCR4 (0.57) | PDE10AKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL16796145 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL4223118 | 0.72 | KCNN2 (0.71) | CTSKCDC7WEE1KDM4EALDH1A1 | |
| SCHEMBL4013492 | 0.69 | MKNK1 (0.62) | MKNK1MKNK2CDK2CDK4GSK3B | |
| SCHEMBL18803580 | 0.69 | MKNK2 (1.00) | MKNK1MKNK2 | |
| SCHEMBL3810192 | 0.67 | MAPK8 (0.70) | MAPK8MAPK9MAPK10CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | claimed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | claimed |
| EP-2074113-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NeuroSearch A/S (DK) | 2009-07-01 | — | — | EP | claimed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | claimed |
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | disclosed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| EP-2074113-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NeuroSearch A/S (DK) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | KCND2, KCNN3, KCNJ2 | MKNK1 1058/4885MKNK2 682/4885MAPK8 3260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.