Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24753371 | 0.85 | NAMPT (0.48) | NAMPTALDH1A1NPC1MAPTHTT | |
| SCHEMBL27363368 | 0.81 | DRD2 (0.43) | — | |
| SCHEMBL27262583 | 0.80 | NAMPT (0.52) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL6917548 | 0.77 | NAMPT (0.67) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL7667693 | 0.75 | NAMPT (0.69) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL20354696 | 0.73 | NAMPT (0.66) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL21965379 | 0.73 | NAMPT (0.66) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL3529237 | 0.73 | NAMPT (0.56) | NAMPTMAPTPTPN2PTPN1PTPN6 | |
| SCHEMBL1992672 | 0.73 | NAMPT (0.58) | NAMPTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL20354579 | 0.73 | NAMPT (0.58) | NAMPTALDH1A1MAPTPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015412-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |