Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PPOX | P50336 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14044153 | 0.92 | P2RX3 (0.44) | GAANPC1P2RX3P2RX2TAAR1 | |
| SCHEMBL18751316 | 0.85 | GAA (0.44) | GAANPC1P2RX3P2RX2POLB | |
| SCHEMBL5166833 | 0.84 | P2RX3 (0.45) | GAAP2RX3P2RX2POLBGFER | |
| SCHEMBL13059718 | 0.82 | GAA (0.48) | GAAP2RX3P2RX2POLBGFER | |
| SCHEMBL12190518 | 0.82 | P2RX3 (0.48) | GAAP2RX3P2RX2POLBGFER | |
| SCHEMBL12781816 | 0.82 | GAA (0.52) | GAANPC1P2RX3P2RX2TAAR1 | |
| SCHEMBL16940691 | 0.79 | LMNA (0.43) | LMNATP53MAPTHPGDSMN1; SMN2 | |
| SCHEMBL171073 | 0.78 | POLB (0.46) | GAAP2RX3P2RX2TAAR1POLB | |
| SCHEMBL8375911 | 0.78 | GAA (0.40) | GAANPC1P2RX3P2RX2TAAR1 | |
| SCHEMBL21142303 | 0.78 | GAA (0.48) | GAAP2RX3P2RX2POLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |