SCHEMBL27264708

SCHEMBL27264708

CCCC(=N)CC1COCCN1C(=O)C1CC(=O)c2ccccc21

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
BACE1 P56817 2/20 0.35
OPRK1 P41145 2/20 0.34
NPC1 O15118 2/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.33
RAB9A P51151 1/20 0.33
GLS O94925 1/20 0.32
LMNA P02545 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
PRMT5 O14744 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27316772 0.99 L3MBTL1 (0.35) L3MBTL1MEN1KMT2ASMN1; SMN2BACE1
SCHEMBL27329759 0.89 HCRTR1 (0.35) MEN1KMT2ASMN1; SMN2NPC1POLB
SCHEMBL27264710 0.87 UTS2R (0.37) L3MBTL1OPRK1NPC1
Hydrochloric Acid SCHEMBL27305166 0.86 UTS2R (0.36) L3MBTL1MEN1KMT2AOPRK1NPC1
Hydrochloric Acid SCHEMBL27302436 0.83 MEN1 (0.38) L3MBTL1MEN1KMT2ASMN1; SMN2BACE1
SCHEMBL27264883 0.82 MEN1 (0.36) L3MBTL1MEN1KMT2AOPRK1POLB
SCHEMBL8558296 0.79 OPRK1 (0.48) L3MBTL1MEN1KMT2AOPRK1GLS
Hydrochloric Acid SCHEMBL8558540 0.78 OPRK1 (0.48) L3MBTL1MEN1KMT2AOPRK1GLS
SCHEMBL27329755 0.74 MAPT (0.37) MEN1KMT2ANPC1POLBRAB9A
Hydrochloric Acid SCHEMBL27296067 0.73 MAPT (0.36) MEN1KMT2ANPC1POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1030450-C Preparation of analgesic carboxylic acid amides derivative SANKYO CO (JP) 1995-12-06 CN disclosed
CN-1079740-A The preparation method of analgesic carboxylic acid amide derivatives SANKYO CO (JP) 1993-12-22 CN disclosed
CN-1079741-A The preparation method of analgesic carboxylic acid amide derivatives SANKYO CO (JP) 1993-12-22 CN disclosed
CN-1078461-A The preparation method of analgesic carboxylic acid amide derivatives SANKYO CO (JP) 1993-11-17 CN disclosed
CN-1022185-C Process for preparing analgesic carboxylic acid amide derivatives SANKYO CO (JP) 1993-09-22 CN disclosed
CN-1040791-A ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES SANKYO CO (JP) 1990-03-28 CN disclosed