Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27270154 | 0.96 | NR1H4 (0.36) | NR1H4ALDH1A1HTTNR1H2MEN1 | |
| SCHEMBL27267291 | 0.81 | ALDH1A1 (0.46) | NR1H4ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL31392992 | 0.81 | NR1H2 (0.36) | NR1H2MEN1KMT2AHTR2C | |
| SCHEMBL6351465 | 0.80 | NR1H4 (0.40) | NR1H4ALDH1A1NR1H2MEN1KMT2A | |
| SCHEMBL30839692 | 0.79 | FSCN1 (0.43) | NR1H4ALDH1A1NR1H2MEN1KMT2A | |
| SCHEMBL14976496 | 0.79 | MEN1 (0.40) | ALDH1A1HTTNR1H2MEN1KMT2A | |
| SCHEMBL27267614 | 0.78 | CNR2 (0.35) | NR1H4ALDH1A1HTTNR1H2CYP3A4 | |
| SCHEMBL27270132 | 0.77 | ALDH1A1 (0.42) | NR1H4ALDH1A1HTTKMT2AHSD11B1 | |
| SCHEMBL3931511 | 0.74 | MEN1 (0.41) | ALDH1A1HTTNR1H2MEN1KMT2A | |
| SCHEMBL27576247 | 0.74 | LMNA (0.39) | ALDH1A1HTTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |