Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.36 |
| ▸ | HTR2B | P41595 | 10/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13778 | 0.81 | HTR2C (0.57) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL13777 | 0.81 | HTR2C (0.57) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL25254330 | 0.81 | HTR2C (0.57) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL22158730 | 0.80 | CYP2A6 (0.53) | MAOBKDM1AMAOA | |
| SCHEMBL22158732 | 0.80 | CYP2A6 (0.53) | MAOBKDM1AMAOA | |
| SCHEMBL6250926 | 0.78 | KDM1A (0.43) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL6251810 | 0.77 | HTR2C (0.61) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL25004709 | 0.75 | HTR2C (0.41) | HTR2CHTR2BHTR2AMAOBKDM1A | |
| SCHEMBL15255147 | 0.75 | HTR2C (0.64) | HTR2CHTR2BHTR2AMAOBSLC6A2 | |
| SCHEMBL25053928 | 0.75 | HTR2C (0.41) | HTR2CHTR2BHTR2AMAOBKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024130065-A1 | SUBSTITUTED DIHYDROPYRROLO[3, 4-D]PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2024-06-20 | — | — | WO | disclosed |