Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27267923 | 0.88 | KCNA5 (0.35) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| SCHEMBL27266927 | 0.78 | CYP17A1 (0.33) | CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL27274400 | 0.67 | CYP51A1 (0.32) | ALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL29864658 | 0.65 | MAPT (0.55) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| SCHEMBL3048607 | 0.65 | MAPT (0.55) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| Hydrochloric Acid SCHEMBL10324019 | 0.64 | MAPT (0.53) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| SCHEMBL28799220 | 0.64 | MAPT (0.53) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| SCHEMBL10501719 | 0.63 | ALDH1A1 (0.40) | ALDH1A1CYP1A2MAPTTP53KCNA5 | |
| SCHEMBL506917 | 0.63 | KCNA5 (0.52) | ALDH1A1CYP1A2TP53KCNA5KCNJ5 | |
| SCHEMBL29767197 | 0.63 | KCNA5 (0.52) | ALDH1A1CYP1A2TP53KCNA5KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031264-C | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | CN | disclosed |
| CN-1019197-B | Preparation of 1-3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEVTICALS IN (US) | 1992-11-25 | — | — | CN | disclosed |
| CN-1057261-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMACOUTICALS IN (US) | 1991-12-25 | — | — | CN | disclosed |
| CN-1055737-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMA (US) | 1991-10-30 | — | — | CN | disclosed |
| CN-85106722-A | Preparation of 1, 3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | — | 1987-03-25 | — | — | CN | disclosed |