Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27275820 | 0.88 | ALDH1A1 (0.36) | KCNA5KCNJ5KCNJ3SCN5AKCND3 | |
| SCHEMBL27274400 | 0.80 | CYP51A1 (0.32) | ALDH1A1MAPTCYP3A4KDM4E | |
| Pyridine SCHEMBL27267301 | 0.70 | TDP1 (0.37) | KCNH2 | |
| SCHEMBL27266927 | 0.67 | CYP17A1 (0.33) | LMNACYP3A4SMN1; SMN2 | |
| SCHEMBL10502325 | 0.67 | POLB (0.38) | KCNA5KCNJ5KCNJ3SCN5AKCND3 | |
| Pyridine SCHEMBL27266528 | 0.65 | TDP1 (0.36) | — | |
| SCHEMBL7275282 | 0.64 | KCNA5 (0.50) | KCNA5KCNJ5KCNJ3SCN5AKCND3 | |
| SCHEMBL1526122 | 0.64 | KCNA5 (0.50) | KCNA5KCNJ5KCNJ3SCN5AKCND3 | |
| SCHEMBL8889041 | 0.63 | MAPT (0.44) | KCNA5KCNJ5KCNJ3SCN5AKCND3 | |
| SCHEMBL8986648 | 0.63 | KCNA5 (0.49) | KCNA5KCNJ5KCNJ3SCN5AKCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031264-C | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | CN | disclosed |
| CN-1019197-B | Preparation of 1-3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEVTICALS IN (US) | 1992-11-25 | — | — | CN | disclosed |
| CN-1057261-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMACOUTICALS IN (US) | 1991-12-25 | — | — | CN | disclosed |
| CN-1055737-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMA (US) | 1991-10-30 | — | — | CN | disclosed |
| CN-85106722-A | Preparation of 1, 3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | — | 1987-03-25 | — | — | CN | disclosed |