Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.71 |
| ▸ | MAOB | P27338 | 6/20 | 0.70 |
| ▸ | APP | P05067 | 4/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.66 |
| ▸ | BACE1 | P56817 | 2/20 | 0.66 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21710514 | 1.00 | DHODH (0.71) | DHODHMAOBAPPPTPN1BACE1 | |
| SCHEMBL2728077 | 1.00 | DHODH (0.71) | DHODHMAOBAPPPTPN1BACE1 | |
| SCHEMBL16224871 | 0.99 | DHODH (0.73) | DHODHMAOBAPPPTPN1BACE1 | |
| SCHEMBL29378394 | 0.99 | DHODH (0.73) | DHODHMAOBAPPPTPN1BACE1 | |
| SCHEMBL31545985 | 0.85 | MAOB (0.83) | MAOBAPPPTPN1BACE1PTGES | |
| SCHEMBL19846967 | 0.85 | MAOB (0.83) | MAOBAPPPTPN1BACE1PTGES | |
| Piperogalin SCHEMBL24074956 | 0.83 | MAOB (0.81) | MAOBAPPPTPN1BACE1PTGES | |
| Piperogalin SCHEMBL30086807 | 0.83 | MAOB (0.81) | MAOBAPPPTPN1BACE1PTGES | |
| SCHEMBL23686894 | 0.82 | DHODH (0.67) | DHODHMAOBAPPPTPN1BACE1 | |
| SCHEMBL29539017 | 0.82 | DHODH (1.00) | DHODHMAOBAPPPTPN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230095374-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | GLIAPHARM SA (CH) | 2023-03-30 | — | — | US | disclosed |
| US-20200405676-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | GLIAPHARM SA (CH) | 2020-12-31 | — | — | US | disclosed |
| EP-3681488-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | Société des Produits Nestlé S.A. (CH) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019053159-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | NESTEC S.A. (CH) | 2019-03-21 | — | — | WO | disclosed |
| EP-2857010-B1 | DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR | INST OF MITOCHONDRIA SCIENCE INC (JP) | 2018-07-04 | — | — | EP | disclosed |
| US-9737504-B2 | Dihydroorotic and acid dehydrogenase inhibitor | INSTITUTE OF MITOCHONDRIA SCIENCE, INC. (JP) | 2017-08-22 | — | — | US | disclosed |
| US-20160296494-A1 | DIHYDROOROTIC AND ACID DEHYDROGENASE INHIBITOR | NAI INC. | 2016-10-13 | — | — | US | disclosed |
| US-9440913-B2 | Dihydroxybenzene derivatives and antiprotozoal agent comprising same as active ingredient | NAI INC. (JP) | 2016-09-13 | — | — | US | disclosed |
| US-20150166498-A1 | DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR | NAI INC. (JP) | 2015-06-18 | — | — | US | disclosed |
| CN-104582694-A | Dihydroorotic acid dehydrogenase inhibitor | NAI INC | 2015-04-29 | — | — | CN | disclosed |
| EP-2857010-A1 | DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR | NAI Inc. (JP) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013180140-A1 | DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR | エヌエーアイ株式会社 (JP) | 2013-12-05 | — | — | WO | disclosed |
| US-20130296422-A1 | Novel Dihydroxybenzene Derivatives and Antiprotozoal Agent Comprising Same as Active Ingredient | ARIGEN PHARMACEUTICALS, INC. (JP) | 2013-11-07 | — | — | US | disclosed |
| EP-2636663-A1 | NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT | aRigen Pharmaceuticals, Inc. (JP) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012060387-A1 | NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT | アリジェン製薬株式会社 (JP) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166498-A1 | DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR | DHODH, DPYD, DLD | DHODH 1/4885MAOB 1308/4885APP 4801/4885 |
| US-20130296422-A1 | Novel Dihydroxybenzene Derivatives and Antiprotozoal Agent Comprising Same as Active Ingredient | CBR3, CBR1, DHX35 | DHODH 16/4885MAOB 811/4885APP 4666/4885 |
| US-20160296494-A1 | DIHYDROOROTIC AND ACID DEHYDROGENASE INHIBITOR | DHODH, DPYD, DLD | DHODH 1/4885MAOB 1150/4885APP 4823/4885 |
| US-20200405676-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | NLN, SLC6A13, SLC6A11 | DHODH 1894/4885MAOB 700/4885APP 68/4885 |
| US-20230095374-A1 | MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER | NLN, SLC6A13, SLC6A11 | DHODH 1894/4885MAOB 700/4885APP 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.