SLC6A13

Sodium- and chloride-dependent GABA transporter 2 · Q9NSD5 · SLC6A13 on Sugi Atlas →

13,711 patent compounds predicted against SLC6A13, 5,702 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1249676 SCHEMBL1249676 0.57 6/20
SCHEMBL1249678 SCHEMBL1249678 0.57 6/20
SCHEMBL1249680 SCHEMBL1249680 0.57 6/20
SCHEMBL1251294 SCHEMBL1251294 0.57 6/20
SCHEMBL1251296 SCHEMBL1251296 0.57 6/20
SCHEMBL431287 SCHEMBL431287 0.54 5/20
SCHEMBL1493230 SCHEMBL1493230 0.54 5/20
SCHEMBL200896 SCHEMBL200896 0.50 5/20
SCHEMBL200897 SCHEMBL200897 0.50 5/20
SCHEMBL229034 SCHEMBL229034 0.50 5/20
SCHEMBL336991 SCHEMBL336991 0.43 5/20
SCHEMBL1067170 SCHEMBL1067170 0.40 5/20
SCHEMBL44023 SCHEMBL44023 0.69 4/20
SCHEMBL1225755 SCHEMBL1225755 0.77 3/20
SCHEMBL1401433 SCHEMBL1401433 0.61 3/20
SCHEMBL1401434 SCHEMBL1401434 0.61 3/20
SCHEMBL1401472 SCHEMBL1401472 0.59 3/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL1609057) 0.59 3/20
SCHEMBL45098 SCHEMBL45098 0.57 3/20
SCHEMBL377179 SCHEMBL377179 0.54 3/20

Clinical trials — most relevant to SLC6A13 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia PHASE2/PHASE3COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm PHASE1/PHASE2COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Effects of Baclofen on Presynaptic Inhibition in Humans PHASE2WITHDRAWN
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Pilot Study of Bumetanide for Newborn Seizures PHASE1COMPLETED
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia PHASE1COMPLETED
Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy EARLY_PHASE1ACTIVE_NOT_RECRUITING
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Analgesic Effect of Oxytocin Receptor Modulation nanCOMPLETED
GABA Biomarkers in Dravet Syndrome nanRECRUITING
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION
Pharmacokinetics Study of Gamma-aminobutyric Acid nanCOMPLETED
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle nanCOMPLETED
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI nanCOMPLETED
Clinical-Genetic Variation in GABA/Alcohol Sensitivity nanCOMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only nanENROLLING_BY_INVITATION
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency nanCOMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder nanUNKNOWN
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
MRS Measurement of Glutamate and GABA Metabolism in Brain nanRECRUITING
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Insulin Detemir in Obesity Management nanACTIVE_NOT_RECRUITING
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC6A13 binder may also engage these)

ProteinNameSimilarity
P31646 1.000 P31646 →
P31661 1.000 P31661 →
P28570 1.000 P28570 →
SLC6A11 Sodium- and chloride-dependent GABA transporter 3 1.000 landscape →
P31649 1.000 P31649 →
SLC6A6 Sodium- and chloride-dependent taurine transporter 1.000 landscape →
Q9MZ34 1.000 Q9MZ34 →
Q28039 1.000 Q28039 →
P31647 1.000 P31647 →
P48029 1.000 P48029 →
SLC6A12 Sodium- and chloride-dependent betaine transporter 1.000 landscape →
Q9MYX0 1.000 Q9MYX0 →
P27799 1.000 P27799 →
P31652 1.000 P31652 →
P51143 1.000 P51143 →
O35316 1.000 O35316 →
P31650 1.000 P31650 →
Q2PG55 1.000 Q2PG55 →
Q00589 1.000 Q00589 →
Q91502 1.000 Q91502 →
P48055 1.000 P48055 →
P48057 1.000 P48057 →
Q9GJT6 1.000 Q9GJT6 →
Q9NP91 1.000 Q9NP91 →
O88575 1.000 O88575 →
P51905 1.000 P51905 →
P31643 1.000 P31643 →
Q8VBW1 1.000 Q8VBW1 →
SLC6A3 Sodium-dependent dopamine transporter 1.000 landscape →
Q8VDB9 1.000 Q8VDB9 →