SCHEMBL2728626

SCHEMBL2728626

C[Si](C)(C)OC1=CCCC1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL817040 0.93 ALDH1A1 (0.33)
SCHEMBL2386422 0.91 ALDH1A1 (0.32)
SCHEMBL2386417 0.91 ALDH1A1 (0.32)
SCHEMBL28488936 0.91 ALDH1A1 (0.32)
SCHEMBL29040729 0.86 P2RX7 (0.32) P2RX7
SCHEMBL5264454 0.82
SCHEMBL10979425 0.80
SCHEMBL3456698 0.79
SCHEMBL14269373 0.79 PREP (0.31)
SCHEMBL7258256 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200388876-A1 SILICON-BASED ENERGY STORAGE DEVICES WITH SILICON CONTAINING ELECTROLYTE ADDITIVES ENEVATE CORPORATION 2020-12-10 US claimed
US-7183354-B2 Room temperature curable functionalized HNBR coating LORD CORPORATION (US) 2007-02-27 US claimed
JP-3086840-A None JP disclosed
EP-4658644-A1 2-(PYRIDAZIN-3-YL)-5-(TRIFLUOROMETHYL)PHENOLS AS NLRP3 INHIBITORS Janssen Pharmaceutica NV (BE) 2025-12-10 EP disclosed
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2025-03-20 US disclosed
CN-114716381-B Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2025-03-11 CN disclosed
CN-114605327-B Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2025-03-11 CN disclosed
CN-114573510-B Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2025-02-25 CN disclosed
US-12220401-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2025-02-11 US disclosed
CN-114591242-B Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2025-01-07 CN disclosed
CN-114341228-B Cyclic polymer hydride, process for producing the same, and resin composition 日本瑞翁株式会社 2024-11-26 CN disclosed
WO-1999017878-A1 USE OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE, IN ADDITION TO ALKALINE METAL SALTS AND ALKALINE-EARTH METAL SALTS THEREOF AS CATALYSTS DURING C-C BONDING SYNTHESES AND THE NOVEL Mg SALT OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE MERCK PATENT GMBH (DE) 1999-04-15 WO disclosed
WO-1998026028-A1 FUEL COMPOSITIONS EXHIBITING IMPROVED FUEL STABILITY ORR WILLIAM C (US) 1998-06-18 WO disclosed
US-5338736-A Treating congestive heart failure, hypertension AMERICAN CYANAMID COMPANY (US) 1994-08-16 US disclosed
JP-H0386840-A PRODUCTION OF ALPHA,BETA-UNSATURATED CARBONYL COMPOUND NIPPON ZEON CO LTD 1991-04-11 JP disclosed
EP-0194077-A1 Improvements in or relating to pheromones NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-09-10 EP disclosed
WO-1986004897-A1 IMPROVEMENTS IN OR RELATING TO PHEROMONES NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-08-28 WO disclosed
US-4495330-A SILANE SCAVENGER IN ONE PACKAGE MOISTURE CURABLE COMPOSITION GENERAL ELECTRIC COMPANY (US) 1985-01-22 US disclosed
US-4430497-A PRESENCE OF LEWIS ACID GRUENENTHAL GMBH (DE) 1984-02-07 US disclosed
EP-0059307-A1 Preparation of 2-oxa-bicyclo(3.3.0)octane compounds and their derivatives Grünenthal GmbH (DE) 1982-09-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12220401-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK P2RX7 2246/4885
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK P2RX7 2246/4885
US-20200388876-A1 SILICON-BASED ENERGY STORAGE DEVICES WITH SILICON CONTAINING ELECTROLYTE ADDITIVES SELENOI, SIK1, SIK2 P2RX7 3699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.