Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.46 |
| ▸ | IL1B | P01584 | 7/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NPR1 | P16066 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27289106 | 0.93 | NLRP3 (0.48) | NLRP3KAT2BIL1BMAPK11MAPK14 | |
| SCHEMBL27289122 | 0.90 | KAT2B (0.46) | NLRP3KAT2BIL1B | |
| SCHEMBL27289128 | 0.89 | KAT2B (0.51) | NLRP3KAT2BIL1B | |
| SCHEMBL27288788 | 0.89 | IL1B (0.55) | NLRP3KAT2BIL1B | |
| SCHEMBL30718303 | 0.89 | IL1B (0.55) | NLRP3KAT2BIL1B | |
| SCHEMBL27297288 | 0.85 | NLRP3 (0.58) | NLRP3KAT2BIL1B | |
| SCHEMBL26112889 | 0.84 | NLRP3 (0.60) | NLRP3KAT2BIL1B | |
| SCHEMBL26093572 | 0.84 | KAT2B (0.50) | NLRP3KAT2BIL1B | |
| SCHEMBL26093567 | 0.84 | KAT2B (0.50) | NLRP3KAT2BIL1B | |
| SCHEMBL27289110 | 0.82 | KAT2B (0.45) | NLRP3KAT2BIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006559-A1 | MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS | Neumora Therapeutics, Inc. (US) | 2024-01-04 | — | — | WO | disclosed |