Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 11/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923245 | 1.00 | TYK2 (0.43) | TYK2JAK1SYKJAK3AXL | |
| SCHEMBL27291200 | 0.95 | SYK (0.47) | TYK2JAK1SYKJAK3 | |
| SCHEMBL30923162 | 0.95 | SYK (0.47) | TYK2JAK1SYKJAK3 | |
| SCHEMBL27293280 | 0.92 | SYK (0.41) | TYK2JAK1SYKJAK3AXL | |
| SCHEMBL27417191 | 0.81 | JAK3 (0.49) | TYK2JAK1SYKJAK3AXL | |
| SCHEMBL27291099 | 0.80 | SYK (0.48) | TYK2JAK1SYKJAK3 | |
| SCHEMBL27293318 | 0.80 | TYK2 (0.44) | TYK2JAK1SYKAXL | |
| SCHEMBL27293373 | 0.79 | JAK1 (0.44) | TYK2JAK1SYKJAK3AXL | |
| SCHEMBL27298258 | 0.77 | TYK2 (0.44) | TYK2JAK1SYKAXL | |
| SCHEMBL27294015 | 0.77 | TYK2 (0.59) | TYK2JAK1JAK3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |