Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Sarcosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | CTH | P32929 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sarcosine SCHEMBL2188433 | 0.89 | GLRA1 (0.40) | GLRA1SLC6A9OR51E2EGLN1KDM4E | |
| Sarcosine SCHEMBL26641423 | 0.88 | LDHA (0.44) | GLRA1SLC6A9OR51E2EGLN1KDM4E | |
| Sarcosine SCHEMBL31427574 | 0.88 | — | — | |
| Sarcosine SCHEMBL156329 | 0.88 | LDHA (0.44) | GLRA1SLC6A9OR51E2EGLN1KDM4E | |
| Sarcosine SCHEMBL149 | 0.88 | — | — | |
| Sarcosine SCHEMBL28259932 | 0.88 | — | — | |
| Sarcosine SCHEMBL10395802 | 0.87 | GLRA1 (0.42) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Sarcosine SCHEMBL4962879 | 0.86 | CTH (0.39) | GLRA1SLC6A9OR51E2EGLN1KDM4E | |
| Sarcosine SCHEMBL25435381 | 0.85 | — | — | |
| Sarcosine SCHEMBL16162573 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4375377-A1 | SUBSTANCE DETECTION METHOD USING AMINOACYLASE | Josho Gakuen Educational Foundation (JP) | 2024-05-29 | — | — | EP | disclosed |
| US-20240060080-A1 | SYNTHETIC DESALINATION GENETIC CIRCUIT IN PLANTS | UNIV COLORADO STATE RES FOUND (US) | 2024-02-22 | — | — | US | disclosed |
| CN-117425733-A | Substance detection method using acylated amino acid hydrolase | 学校法人常翔学园 | 2024-01-19 | — | — | CN | disclosed |
| US-20230390250-A1 | MODULATION OF GLUCAGON-LIKE PEPTIDE 1 AND USES THEREOF | DUNCAN ROBIN ELAINE (CA) | 2023-12-07 | — | — | US | disclosed |
| US-20230220443-A1 | CHARACTERIZATION OF S-ADENOSYL-L-METHIONINE-CONSUMING ENZYMES WITH 1-STEP EZ-MTASE: A UNIVERSAL COUPLED-ASSAY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
| US-11692199-B2 | Synthetic desalination genetic circuit in plants | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2023-07-04 | — | — | US | disclosed |
| WO-2023002821-A1 | SUBSTANCE DETECTION METHOD USING AMINOACYLASE | 学校法人常翔学園 | 2023-01-26 | — | — | WO | disclosed |
| CN-113263812-B | Laminate for battery outer package, and battery | 藤森工业株式会社 | 2022-11-29 | — | — | CN | disclosed |
| US-20220213040-A1 | CATECHOLAMINE CARBAMATE PRODRUGS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE | H. LUNDBECK A/S (DK) | 2022-07-07 | — | — | US | disclosed |
| WO-2022087749-A1 | MODULATION OF GLUCAGON-LIKE PEPTIDE 1 AND USES THEREOF | DUNCAN ROBIN ELAINE (CA) | 2022-05-05 | — | — | WO | disclosed |
| US-6083913-A | TREATING BLOOD DISORDERS | GLAXO WELLCOME INC. (US) | 2000-07-04 | — | — | US | disclosed |
| WO-2000011142-A2 | METHYLTRANSFERASES, NUCLEIC ACID MOLECULES ENCODING METHYLTRANSFERASES, THEIR RECOMBINANT EXPRESSION AND USES THEREOF | DANISCO FINLAND OY (FI) | 2000-03-02 | — | — | WO | disclosed |
| EP-0861264-A2 | COLLAGEN-LIKE PEPTOID RESIDUE-CONTAINING STRUCTURES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997019106-A2 | COLLAGEN-LIKE PEPTOID RESIDUE-CONTAINING STRUCTURES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-05-29 | — | — | WO | disclosed |
| US-5091561-A | Oxidation of N-phosphonamethyliminodiacetic acid using molecular oxygen and transition metal catalyst | MONSANTO COMPANY (US) | 1992-02-25 | — | — | US | disclosed |
| US-4965402-A | CATALYTIC OXIDATION OF N-PHOSPHONOMETHYLIMINODIACETIC ACID | MONSANTO COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4853159-A | COBALT CATALYTIC OXIDATION OF N-PHOSPHONOMETHYLIMINODIACETIC ACID | MONSANTO COMPANY (US) | 1989-08-01 | — | — | US | disclosed |
| US-4353983-A | ELECTROCHEMISTRY | BATTELLE MEMORIAL INSTITUTE (CH) | 1982-10-12 | — | — | US | disclosed |
| EP-0020623-A1 | ANALYTICAL PROCESS AND MEANS FOR MEASURING THE AMOUNT OF HYDROGEN PEROXIDE IN AQUEOUS MEDIA AND OF ORGANIC SUBSTRATES GENERATING HYDROGEN PEROXIDE BY ENZYMATIC OXIDATION. | BATTELLE MEMORIAL INSTITUTE (CH) | 1981-01-07 | — | — | EP | disclosed |
| WO-1980001081-A1 | ANALYTICAL PROCESS AND MEANS FOR MEASURING THE AMOUNT OF HYDROGEN PEROXIDE IN AQUEOUS MEDIA AND OF ORGANIC SUBSTRATES GENERATING HYDROGEN PEROXIDE BY ENZYMATIC OXIDATION | BATTELLE MEMORIAL INSTITUTE (CH) | 1980-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213040-A1 | CATECHOLAMINE CARBAMATE PRODRUGS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE | COMT, CHAT, SLC6A2 | GLRA1 2888/4885SLC6A9 958/4885OR51E2 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.