Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Sarcosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRE | P78334 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL11511190 | 0.94 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Alanine SCHEMBL28294968 | 0.94 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Sarcosine SCHEMBL2368384 | 0.94 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Sarcosine SCHEMBL17258535 | 0.89 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Sarcosine SCHEMBL272983 | 0.87 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2ALDH1A1LMNA | |
| Sarcosine SCHEMBL9470529 | 0.86 | GABRP (0.41) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Alanine SCHEMBL9470521 | 0.86 | GABRP (0.41) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Sarcosine SCHEMBL27642283 | 0.84 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| Alanine SCHEMBL25189736 | 0.84 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD | |
| Alanine SCHEMBL1675385 | 0.84 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921941-A | TRIPEPTIDE ESTERS | SCHERING CORPORATION (US) | 1990-05-01 | — | — | US | disclosed |