Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730233 | 0.87 | L3MBTL1 (0.47) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL2362965 | 0.83 | SCN9A (0.45) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10172563 | 0.73 | PTGDR2 (0.43) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL27006465 | 0.73 | STAT3 (0.49) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL7972107 | 0.72 | RAB9A (0.45) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL2731515 | 0.70 | TDP1 (0.43) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10962251 | 0.70 | TP53 (0.57) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10958929 | 0.70 | TP53 (0.57) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL27006451 | 0.69 | LMNA (0.51) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL29272617 | 0.69 | SMN1; SMN2 (0.42) | MAPTALDH1A1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-B1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2632269-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |