Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27674900 | 0.90 | PTK2B (0.41) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL8498810 | 0.87 | KMT2A (0.50) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL13505905 | 0.87 | MEN1 (0.50) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL7049564 | 0.85 | MEN1 (0.49) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL8496997 | 0.85 | MEN1 (0.49) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL8496813 | 0.83 | PTK2B (0.47) | KMT2AMEN1KDM4ERECQLPTK2B | |
| SCHEMBL27817781 | 0.83 | KMT2A (0.41) | KMT2AMEN1KDM4ERECQLALDH1A1 | |
| SCHEMBL27632196 | 0.81 | ALDH1A1 (0.50) | KMT2AMEN1KDM4ERECQLCXCL8 | |
| SCHEMBL29081006 | 0.81 | KMT2A (0.49) | KMT2AMEN1KDM4ERECQLALDH1A1 | |
| SCHEMBL27487420 | 0.81 | KMT2A (0.43) | KMT2AMEN1KDM4ERECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115755-B | Pyrazolo-pyrimidine derivatives as MGLUR2 antagonists | HOFFMANN LA ROCHE | 2013-01-16 | — | — | CN | disclosed |
| CN-102164896-A | Phenethylamide derivatives and their heterocyclic analogues | ACTELION PHARMACEUTICALS LTD | 2011-08-24 | — | — | CN | disclosed |
| CN-101952275-A | Modulators for amyloid beta | HOFFMANN LA ROCHE | 2011-01-19 | — | — | CN | disclosed |
| CN-101180299-B | Ethynyl-pyrazolopyrimidine derivatives as MGLUR2 antagonists | HOFFMANN LA ROCHE | 2010-12-15 | — | — | CN | disclosed |
| CN-101321763-A | Pyrazolo [1,5-a] pyrimidines as protein kinase inhibitors | SCHERING CORP (US) | 2008-12-10 | — | — | CN | disclosed |
| CN-101180299-A | Ethynyl-pyrazolopyrimidine derivatives as MGLUR2 antagonists | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | CN | disclosed |
| CN-1671710-A | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | NEOGENESIS PHARMACEUTICALS INC (US) | 2005-09-21 | — | — | CN | disclosed |
| CN-1030682-C | Method for preparating N-aryl-3-aryl-4.5-dihydro-IH-pyrazole-l-carboxamides | ROHM AND HASS CORP (US) | 1996-01-17 | — | — | CN | disclosed |