Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MPO | P05164 | 3/20 | 0.54 |
| ▸ | XDH | P47989 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731359 | 0.83 | KMT2A (0.70) | KDM4EKMT2ASMN1; SMN2MPOXDH | |
| SCHEMBL9630208 | 0.80 | ALDH1A1 (0.62) | KDM4EKMT2ASMN1; SMN2MPOALDH1A1 | |
| SCHEMBL15215602 | 0.77 | MPO (0.58) | KDM4EKMT2AMPOXDHALDH1A1 | |
| SCHEMBL22281511 | 0.76 | KMT2A (0.67) | KDM4EKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2915423 | 0.76 | KDM4E (0.71) | KDM4EKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2915065 | 0.74 | KDM4E (0.65) | KDM4EKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2911602 | 0.73 | KDM4E (0.70) | KDM4EKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL23830045 | 0.73 | PARP1 (0.68) | KDM4EKMT2AALDH1A1PARP1HSD17B10 | |
| SCHEMBL29620678 | 0.73 | PARP1 (0.68) | KDM4EKMT2AALDH1A1PARP1HSD17B10 | |
| SCHEMBL4252129 | 0.73 | KDM4E (0.64) | KDM4EKMT2ASMN1; SMN2ALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632466-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | Emory University (US) | 2013-09-04 | — | — | EP | claimed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | claimed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | claimed |
| US-9868728-B2 | Quinazoline derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | NOX4, NOX5, NQO2 | KDM4E 1311/4885KMT2A 1366/4885SMN1; SMN2 4538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.