Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.87 |
| ▸ | MEN1 | O00255 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | APEX1 | P27695 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL8994290 | 0.97 | MEN1 (0.80) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL8383204 | 0.93 | MEN1 (0.75) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL30612764 | 0.93 | — | — | |
| Choline SCHEMBL28574484 | 0.93 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL29499824 | 0.93 | — | — | |
| Choline SCHEMBL9391204 | 0.93 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL2459999 | 0.93 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL1332010 | 0.93 | — | — | |
| Choline SCHEMBL14957 | 0.93 | — | — | |
| Choline SCHEMBL1330530 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113201565-A | Method for improving catalytic efficiency of whole-cell preparation of D-psicose based on eutectic solvent | 中国科学院广州能源研究所 | 2021-08-03 | — | — | CN | claimed |
| CN-108786763-A | The preparation method of the gold nanorods doping integral post of mesoporous silicon oxide cladding | 天津医科大学 | 2018-11-13 | — | — | CN | claimed |
| CN-117925750-A | Method for extracting houttuynia cordata polysaccharide | 浙江工业大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-115739028-B | Psychoactive substance adsorbent and application thereof | 西南政法大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-117247706-A | Inorganic graphene zinc-rich coating and preparation method thereof | 南京长江涂料有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-117247706-A | Inorganic graphene zinc-rich coating and preparation method thereof | 南京长江涂料有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-115491094-B | Normal-temperature-cured fluorocarbon coating and preparation method thereof | 浙江鱼童新材料股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-111389413-B | Multi-copper platinum silver composite metal catalyst, preparation method and application | 江苏大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-115739028-A | Psychoactive substance adsorbent and application thereof | 西南政法大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-115491094-A | Normal-temperature curing fluorocarbon coating and preparation method thereof | 浙江鱼童新材料股份有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-115089995-A | Guava leaf total flavone, extraction method and application | 河池学院 | 2022-09-23 | — | — | CN | disclosed |
| CN-112143299-B | Long-acting self-cleaning high-weatherability fluorocarbon coating and preparation method thereof | 南京长江涂料有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-112143299-B | Long-acting self-cleaning high-weatherability fluorocarbon coating and preparation method thereof | 南京长江涂料有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113201565-A | Method for improving catalytic efficiency of whole-cell preparation of D-psicose based on eutectic solvent | 中国科学院广州能源研究所 | 2021-08-03 | — | — | CN | disclosed |
| CN-112143299-A | Long-acting self-cleaning high-weatherability fluorocarbon coating and preparation method thereof | 南京长江涂料有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-112143299-A | Long-acting self-cleaning high-weatherability fluorocarbon coating and preparation method thereof | 南京长江涂料有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-111389413-A | Multi-copper platinum silver composite metal catalyst, preparation method and application | 江苏大学 | 2020-07-10 | — | — | CN | disclosed |
| CN-108786763-A | The preparation method of the gold nanorods doping integral post of mesoporous silicon oxide cladding | 天津医科大学 | 2018-11-13 | — | — | CN | disclosed |
| CN-108786763-A | The preparation method of the gold nanorods doping integral post of mesoporous silicon oxide cladding | 天津医科大学 | 2018-11-13 | — | — | CN | disclosed |
| CN-1032158-A | The method for preparing diethyl-dithio-carbamate choline | LAFON PHARMA (FR) | 1989-04-05 | — | — | CN | disclosed |