Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.42 |
| ▸ | APEX1 | P27695 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL8383204 | 0.97 | MEN1 (0.75) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27304568 | 0.97 | CYP3A4 (0.87) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27919600 | 0.94 | MEN1 (0.71) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL21380518 | 0.93 | MEN1 (0.80) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL300867 | 0.93 | MEN1 (0.92) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL13169639 | 0.93 | — | — | |
| Choline SCHEMBL8012313 | 0.93 | MEN1 (0.92) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL17629823 | 0.93 | MEN1 (0.92) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL16558587 | 0.93 | — | — | |
| Choline SCHEMBL29394392 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085437-B | Amphipathic derivatives of 3- (1- tert-butoxy carbonyl piperazines -4-yl) propionic acid and application thereof | 上海交通大学 | 2018-07-03 | — | — | CN | claimed |
| CN-105085292-B | Amphipathic derivatives of 3 ((2 (dimethylamino) ethyl group) (methyl) amino) propionic acid and application thereof | 上海交通大学 | 2017-12-15 | — | — | CN | claimed |
| EP-2666773-B1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO LTD (CN) | 2017-07-26 | — | — | EP | claimed |
| US-9233954-B2 | Organic amine salts of Azilsartan, preparation method and use thereof | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-01-12 | — | — | US | claimed |
| EP-2666773-A1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Co., Ltd. (CN) | 2013-11-27 | — | — | EP | claimed |
| US-20130296334-A1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2013-11-07 | — | — | US | claimed |
| CN-114681395-A | Galanthamine hydrobromide cream and preparation method thereof | 鲁南制药集团股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-111138263-B | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-111138263-A | Method for separating phorbol alcohol by utilizing ultrasonic-assisted alcoholysis-extraction coupling technology | 南昌大学 | 2020-05-12 | — | — | CN | disclosed |
| WO-2019188432-A1 | RESIN COMPOSITION AND ELECTRONIC COMPONENT | 日本ゼオン株式会社 | 2019-10-03 | — | — | WO | disclosed |
| CN-105085437-B | Amphipathic derivatives of 3- (1- tert-butoxy carbonyl piperazines -4-yl) propionic acid and application thereof | 上海交通大学 | 2018-07-03 | — | — | CN | disclosed |
| CN-105085292-B | Amphipathic derivatives of 3 ((2 (dimethylamino) ethyl group) (methyl) amino) propionic acid and application thereof | 上海交通大学 | 2017-12-15 | — | — | CN | disclosed |
| CN-107383336-A | A kind of blood compatibility medical polyurethane material and preparation method thereof | 成都优瑞商务服务有限公司 | 2017-11-24 | — | — | CN | disclosed |
| EP-2666773-B1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO LTD (CN) | 2017-07-26 | — | — | EP | disclosed |
| US-9233954-B2 | Organic amine salts of Azilsartan, preparation method and use thereof | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-01-12 | — | — | US | disclosed |
| EP-2666773-A1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Co., Ltd. (CN) | 2013-11-27 | — | — | EP | disclosed |
| US-20130296334-A1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2013-11-07 | — | — | US | disclosed |
| CN-1879788-A | Virus-clearing capsule | GOU CHUNHU (CN) | 2006-12-20 | — | — | CN | disclosed |
| US-5567419-A | IMPROVED STORAGE STABILITY AND ORGANOLEPTIC PROPERTIES | KANEBO LTD. (JP) | 1996-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296334-A1 | ORGANIC AMINE SALTS OF AZILSARTAN, PREPARATION METHOD AND USE THEREOF | REN, AGTR2, AGTR1 | MEN1 1091/4885KMT2A 767/4885LMNA 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.