Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20755330 | 0.79 | LMNA (0.35) | CHRM2HTR1AADRA2AADORA3CHRM1 | |
| SCHEMBL24575856 | 0.74 | CHRM2 (0.58) | CHRM2HTR1AADRA2AADORA3CHRM1 | |
| SCHEMBL23028119 | 0.74 | CHRM2 (0.58) | CHRM2HTR1AADRA2AADORA3CHRM1 | |
| SCHEMBL6124873 | 0.71 | PIK3CD (0.50) | CYP2D6MAOB | |
| SCHEMBL4654050 | 0.71 | ALDH1A1 (0.46) | OPRM1 | |
| SCHEMBL671342 | 0.71 | ALDH1A1 (0.46) | OPRM1 | |
| SCHEMBL21015468 | 0.71 | CHRM2 (0.42) | CHRM2HTR1AADRA2AADORA3CHRM1 | |
| SCHEMBL20234024 | 0.71 | TSHR (0.34) | OPRM1MAOB | |
| SCHEMBL6746315 | 0.70 | DNM1 (0.32) | OPRM1MAOB | |
| SCHEMBL10175178 | 0.70 | MAOB (0.47) | DRD3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006776-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |