SCHEMBL27308486

SCHEMBL27308486

Cc1cccc(C(=O)C#N)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.42
TAS1R3 Q7RTX0 1/20 0.42
TAS1R1 Q7RTX1 1/20 0.42
TAS1R2 Q8TE23 1/20 0.42
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
ENPP3 O14638 1/20 0.37
ALPL P05186 1/20 0.37
XIAP P98170 1/20 0.37
TSHR P16473 2/20 0.37
MYC P01106 1/20 0.37
HTT P42858 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
MAPK1 P28482 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3273583 0.81 TSHR (0.59) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
SCHEMBL3675034 0.80 HPGD (0.46) KDM4EALDH1A1HPGDHSD17B10ENPP3
SCHEMBL23070440 0.78 KMT2A (0.48) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
SCHEMBL697613 0.76 TAS1R3 (0.46) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
SCHEMBL2963108 0.76 P2RX7 (0.46) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
SCHEMBL306828 0.76 TSHR (0.63) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
SCHEMBL2466290 0.75 CLCN2 (0.51) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
Toluene SCHEMBL28735230 0.74 HPGD (0.44) KDM4EALDH1A1HPGDHSD17B10ENPP3
SCHEMBL16019020 0.73 P2RX7 (0.48) P2RX7TAS1R3TAS1R1TAS1R2KDM4E
Hydrochloric Acid SCHEMBL28796608 0.73 CLCN2 (0.50) P2RX7TAS1R3TAS1R1TAS1R2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1037175-C Halomethylbenzoyl cyanides and process for preparing same BASF AG (DE) 1998-01-28 CN disclosed
CN-1030911-C Dibenzoylalkylcyanohydrazines ROHM & HAAS (US) 1996-02-07 CN disclosed
CN-1097412-A Preparation of halomethylbenzoyl cyanides and novel halomethylbenzoyl cyanides BASF AG (DE) 1995-01-18 CN disclosed