Sugi Predict

Sugi Predict / Compounds / SCHEMBL3273583

SCHEMBL3273583

SCHEMBL3273583

N#CC(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.59
▸ ERCC5 P28715 1/20 0.47
▸ FEN1 P39748 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ P2RX7 Q99572 2/20 0.46
▸ JAK2 O60674 1/20 0.44
▸ TAS1R3 Q7RTX0 1/20 0.44
▸ TAS1R1 Q7RTX1 1/20 0.44
▸ TAS1R2 Q8TE23 1/20 0.44
▸ CES2 O00748 1/20 0.43
▸ CES1 P23141 1/20 0.43
▸ ALDH1A1 P00352 4/20 0.42
▸ DHODH Q02127 1/20 0.40
▸ PKM P14618 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ LMNA P02545 1/20 0.39
▸ KMT2A Q03164 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5666023 0.90 TSHR (0.53) TSHRERCC5FEN1HTTP2RX7
SCHEMBL4000363 0.83 CES2 (0.58) TSHRERCC5FEN1CES2CES1
SCHEMBL5666469 0.82 CYP3A4 (0.38) TSHRHTTCES2CES1ALDH1A1
SCHEMBL3930146 0.81 KAT6A (0.43) TSHRP2RX7TAS1R3TAS1R1TAS1R2
SCHEMBL27308486 0.81 P2RX7 (0.42) TSHRHTTP2RX7TAS1R3TAS1R1
Methyl Alcohol SCHEMBL28939417 0.80 CES2 (0.54) ERCC5FEN1CES2CES1ALDH1A1
Acetonitrile SCHEMBL28214755 0.77 TSHR (0.78) TSHRERCC5FEN1HTTP2RX7
SCHEMBL5668300 0.77 ALDH1A1 (0.54) TSHRFEN1JAK2TAS1R3TAS1R1
SCHEMBL7032023 0.76 TSHR (0.71) TSHRERCC5FEN1HTTP2RX7
SCHEMBL7380731 0.76 ERCC5 (0.56) TSHRERCC5FEN1HTTP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113156009-B Method for analyzing lamotrigine by high performance liquid chromatography 三金集团湖南三金制药有限责任公司 2023-12-22 — — CN claimed
CN-106083753-B A kind of improved Lamotrigine synthesis technology 浙江奇彩环境科技股份有限公司 2019-04-02 — — CN claimed
CN-106083753-A A kind of lamotrigine synthesis technique of improvement 浙江奇彩环境科技股份有限公司 2016-11-09 — — CN claimed
CN-103570637-A Preparation method of lamotrigine YANCHENG KAILI PHARMACEUTICAL CO LTD 2014-02-12 — — CN claimed
CN-102070545-A Method for preparing lamotrigine YONG JIANG 2011-05-25 — — CN claimed
US-20100087638-A1 PROCESS FOR THE PREPARATION OF LAMOTRIGINE LONZA AG (CH) 2010-04-08 — — US claimed
US-20090312544-A1 METHOD FOR PREPARING LAMORTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE CALAIRE CHIMIE SAS (FR) 2009-12-17 — — US claimed
EP-2024345-B1 METHOD FOR PREPARING LAMOTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE CALAIRE CHIMIE SAS (FR) 2009-12-16 — — EP claimed
CN-101506178-A A process for the preparation of lamotrigine LONZA AG (CH) 2009-08-12 — — CN claimed
EP-2054396-A1 A PROCESS FOR THE PREPARATION OF LAMOTRIGINE LONZA AG (CH) 2009-05-06 — — EP claimed
EP-1539720-A1 NEW PROCESS FOR THE SYNTHESIS OF HIGH PURITY 3,5-DIAMINO-6-(2, 3-DICHLOROPHENYL)-1,2,4-TRIAZINE RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) 2005-06-15 — — EP claimed
WO-2005003104-A2 CRYSTALLINE FORMS OF LAMOTRIGINE MONOHYDRATE AND ANHYDROUS LAMOTRIGINE AND A PROCESS FOR THEIR PREPARATION JUBILANT ORGANOSYS LIMITED (IN) 2005-01-13 — — WO claimed
WO-2004039767-A1 PROCESS FOR PREPARING A PHARMACEUTICALLY ACTIVE COMPOUND AND FOR PREPARING ITS INTERMEDIATE VITA CIENTIFICA, S.L. (ES) 2004-05-13 — — WO claimed
WO-2004026845-A1 NEW PROCESS FOR THE SYNTHESIS OF HIGH PURITY 3,5-DIAMINO-6-(2, 3-DICHLOROPHENYL)-1,2,4-TRIAZINE Richter Gedeon Vegyészeti Gyár Rt. (HU) 2004-04-01 — — WO claimed
US-6639072-B1 Reductive aminiation of 2,3-dichloronitrobenzene followed by diazotization, hydrolysis, chlorination and cyano dehalogena-tion; condensation of resulting 2,3-dichlorobenzoyl cyanide with aminoguanidine bicarbonate and cyclizing RPG LIFE SCIENCES LIMITED (IN) 2003-10-28 — — US claimed
EP-0963980-B1 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of \"lamotrigine\ WELLCOME FOUND (GB) 2002-06-05 — — EP claimed
US-20020055177-A1 Compound and its use GLAXO WELLCOME INC. 2002-05-09 — — US claimed
US-6333198-B1 ASSAYING SAMPLE OF LAMOTRIGINE OR A PHARMACEUTICAL DOSAGE FORM COMPRISING LAMOTRIGINE IN PRESENCE OF N-(5-AMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-3-YL)-2, 3-DICHLOROBENZAMIDE GLAXO WELLCOME, INC. 2001-12-25 — — US claimed
WO-2001049669-A1 A PROCESS FOR THE PREPARATION OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE-3,5-DIAMINE, COMMONLY KNOWN AS LAMOTRIGINE RPG LIFE SCIENCES LIMITED (IN) 2001-07-12 — — WO claimed
EP-0963980-A2 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of \"lamotrigine\ THE WELLCOME FOUNDATION LIMITED (GB) 1999-12-15 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087638-A1 PROCESS FOR THE PREPARATION OF LAMOTRIGINE SDHA, GABRE, RIMKLA TSHR 4170/4885ERCC5 3500/4885FEN1 2270/4885
US-20090312544-A1 METHOD FOR PREPARING LAMORTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE DLD, DLST, DDO TSHR 2821/4885ERCC5 1145/4885FEN1 3540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.