Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 7/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.36 |
| ▸ | HEXA | P06865 | 2/20 | 0.35 |
| ▸ | HEXB | P07686 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22062839 | 0.81 | REN (0.41) | GABRB3GABRA2GABRB2HEXAHEXB | |
| SCHEMBL22062889 | 0.81 | GABRP (0.38) | GABRB3GABRA2GABRB2HEXAHEXB | |
| SCHEMBL24615642 | 0.77 | HSP90AA1 (0.36) | GABRB3GABRA2GABRB2NOS3NOS2 | |
| SCHEMBL31234990 | 0.77 | HSP90AA1 (0.36) | GABRB3GABRA2GABRB2NOS3NOS2 | |
| SCHEMBL24331214 | 0.76 | BACE1 (0.34) | NOS3NOS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL22029121 | 0.72 | KRAS (0.37) | GABRB3GABRA2GABRB2NOS3NOS2 | |
| SCHEMBL30826909 | 0.72 | KRAS (0.37) | GABRB3GABRA2GABRB2NOS3NOS2 | |
| SCHEMBL27300605 | 0.72 | NOS2 (0.34) | NOS3NOS2CYP3A4CYP2D6KMT2A | |
| SCHEMBL22063480 | 0.70 | BACE1 (0.41) | GABRB3GABRA2GABRB2HEXAHEXB | |
| SCHEMBL22035472 | 0.68 | NOTUM (0.38) | GABRB3GABRA2GABRB2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216516-A1 | GLUTARIMIDE-CONTAINING KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF | TIGER BIOTHERAPEUTICS INC. | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240216516-A1 | GLUTARIMIDE-CONTAINING KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF | KRAS, VHL, HRAS | GABRB3 1908/4885GABRA2 2016/4885GABRB2 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.