Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.40 |
| ▸ | PDE4A | P27815 | 5/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20867 | 0.85 | ATAD2 (0.53) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL27339406 | 0.84 | ATAD2 (0.51) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| Water SCHEMBL27738785 | 0.84 | ADORA2A (0.54) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL27602647 | 0.81 | ATAD2 (0.49) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| Hydrochlorthiazide SCHEMBL27456436 | 0.78 | ATAD2 (0.40) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| Thiophene SCHEMBL27638390 | 0.76 | ATAD2 (0.44) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL17200149 | 0.73 | CRBN (0.41) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL10597948 | 0.71 | PNP (0.46) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL28106050 | 0.71 | ATAD2 (0.39) | ATAD2ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL27310857 | 0.71 | MGMT (0.41) | ATAD2ADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1048493-C | 06-substituted guanine derivatives, a process for their prepn. and their use | CANCER RES CAMPAIGN TECH (GB) | 2000-01-19 | — | — | CN | disclosed |
| CN-1145622-A | O 6Substituted guanine derivatives, process for their preparation and their use | CANCER RES CAMPAIGN TECH (GB) | 1997-03-19 | — | — | CN | disclosed |