Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14068810 | 0.85 | GPR119 (0.48) | PRMT5WDR77RIPK1HCRTR2 | |
| SCHEMBL14077690 | 0.82 | SMN1; SMN2 (0.51) | — | |
| SCHEMBL25900611 | 0.81 | MEN1 (0.44) | MEN1KMT2ARIPK1SLC6A2SLC6A4 | |
| SCHEMBL19500994 | 0.74 | RIPK1 (0.71) | PRMT5WDR77MEN1KMT2ARIPK1 | |
| SCHEMBL22805991 | 0.74 | SLC6A2 (0.47) | RIPK1SLC6A2SLC6A4SLC6A3HCRTR2 | |
| SCHEMBL10002512 | 0.74 | RIPK1 (0.64) | PRMT5WDR77MEN1KMT2ARIPK1 | |
| SCHEMBL22355835 | 0.73 | HCRTR2 (0.67) | HCRTR2 | |
| SCHEMBL22355735 | 0.73 | HCRTR2 (0.67) | HCRTR2 | |
| SCHEMBL22355825 | 0.73 | HCRTR2 (0.67) | HCRTR2 | |
| SCHEMBL12184218 | 0.73 | RIPK1 (0.58) | PRMT5WDR77MEN1KMT2ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081363-A1 | COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER | Revolution Medicines, Inc. (US) | 2024-04-18 | — | — | WO | disclosed |