Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235655 | 0.83 | TDP1 (0.57) | TDP1MAP2K1MAPTALDH1A1HTT | |
| SCHEMBL311206 | 0.83 | TDP1 (0.69) | TDP1MAP2K1MAPTALDH1A1HTT | |
| SCHEMBL30087468 | 0.81 | DHODH (0.57) | TDP1DHODHMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2301749 | 0.81 | DHODH (0.57) | TDP1DHODHMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1373668 | 0.81 | TDP1 (0.58) | TDP1DHODHMAP2K1MAPTALDH1A1 | |
| SCHEMBL22466616 | 0.80 | TDP1 (0.43) | TDP1DHODHMAP2K1ALDH1A1KDM4E | |
| SCHEMBL20916924 | 0.80 | RAB9A (0.55) | DHODHMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29477666 | 0.80 | RAB9A (0.55) | DHODHMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28734386 | 0.80 | TDP1 (0.72) | TDP1ALDH1A1KDM4EATMLMNA | |
| SCHEMBL28797930 | 0.80 | TRPV1 (0.58) | TDP1DHODHMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4587014-A2 | C5AR1 ANTAGONISTS AND USES THEREOF | Vanqua Bio, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| WO-2024059096-A2 | C5AR1 ANTAGONISTS AND USES THEREOF | VANQUA BIO, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2024059096-A2 | C5AR1 ANTAGONISTS AND USES THEREOF | VANQUA BIO, INC. (US) | 2024-03-21 | — | — | WO | disclosed |