Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30087468 | 1.00 | DHODH (0.57) | DHODHNAPRTTDP1KDM4EALDH1A1 | |
| SCHEMBL29477666 | 0.84 | RAB9A (0.55) | DHODHNAPRTKDM4EALDH1A1MAPT | |
| SCHEMBL20916924 | 0.84 | RAB9A (0.55) | DHODHNAPRTKDM4EALDH1A1MAPT | |
| SCHEMBL7372993 | 0.83 | TDP1 (0.52) | DHODHTDP1KDM4EALDH1A1NPSR1 | |
| SCHEMBL30919007 | 0.81 | NAPRT (0.50) | DHODHNAPRTTDP1KDM4EALDH1A1 | |
| SCHEMBL456915 | 0.81 | NAPRT (0.50) | DHODHNAPRTTDP1KDM4EALDH1A1 | |
| SCHEMBL27313359 | 0.81 | TDP1 (0.61) | DHODHTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL24518039 | 0.80 | NAPRT (0.49) | DHODHNAPRTTDP1KDM4EALDH1A1 | |
| SCHEMBL3878750 | 0.80 | NAPRT (0.49) | DHODHNAPRTTDP1KDM4EALDH1A1 | |
| SCHEMBL29959517 | 0.78 | KDM4E (0.57) | DHODHNAPRTTDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160318923-A1 | DIAZEPANE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160318923-A1 | DIAZEPANE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-11-03 | — | — | US | disclosed |
| EP-2350008-A1 | METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES | Bayer CropScience AG (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-4911753-A | Herbicide | AMERICAN CYANAMID COMPANY (US) | 1990-03-27 | — | — | US | disclosed |
| US-4772311-A | Herbicidal 2-(2-imidazolin-2-yl)fluoroalkoxy-, alkenyloxy- and alkynyloxy quinolines | AMERICAN CYANAMID CO. (US) | 1988-09-20 | — | — | US | disclosed |
| US-4647301-A | Herbicidal 2-(2-imidazolin-2-yl)fluoroalkyoxy-, alkenyloxy- and alkynyloxypyridines | AMERICAN CYANAMID COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0166907-A2 | Herbicidal 2-(2-imidazolin-2-yl)-fluoroalkoxy-, alkenyloxy- and alkynyloxypyridines and quinolines | AMERICAN CYANAMID COMPANY (US) | 1986-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318923-A1 | DIAZEPANE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, CRHR1 | DHODH 1360/4885NAPRT 1748/4885TDP1 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.