Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731386 | 1.00 | TSHR (0.37) | TSHRFAAHTRPV1THRBALDH1A1 | |
| SCHEMBL19233520 | 0.89 | CYP1A2 (0.40) | TSHRALDH1A1HPGD | |
| SCHEMBL17336099 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17336102 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17336100 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17921777 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17336058 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17336101 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL17336059 | 0.87 | CYP1A2 (0.39) | TSHREPHX1 | |
| SCHEMBL11762566 | 0.82 | CYP1A2 (0.41) | TSHRALDH1A1HPGDKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635551-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2018-05-02 | — | — | EP | claimed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | claimed |
| EP-2635551-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | Bayer Cropscience AG (DE) | 2013-09-11 | — | — | EP | claimed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | claimed |
| WO-2012059585-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | WO | claimed |
| EP-2635551-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2018-05-02 | — | — | EP | disclosed |
| CN-103402970-B | Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation | 拜耳知识产权有限责任公司 | 2017-02-15 | — | — | CN | disclosed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| US-9260378-B2 | Process for the preparation of substituted N-(benzyl)cyclopropanamines by imine hydrogenation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | disclosed |
| CN-103402970-A | Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation | BAYER IP GMBH | 2013-11-20 | — | — | CN | disclosed |
| EP-2635551-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | Bayer Cropscience AG (DE) | 2013-09-11 | — | — | EP | disclosed |
| EP-2635551-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | Bayer Cropscience AG (DE) | 2013-09-11 | — | — | EP | disclosed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2013-08-22 | — | — | US | disclosed |
| WO-2012059585-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059585-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | BAYER CROPSCIENCE AG (DE) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217910-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION | DHPS, PNMT, INMT | TSHR 4169/4885FAAH 914/4885TRPV1 3758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.