Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732579 | 0.84 | KMT2A (0.45) | KMT2AALDH1A1TSHRKCNJ1NPC1 | |
| SCHEMBL2731679 | 0.83 | ALDH1A1 (0.57) | KMT2AALDH1A1TSHRNPC1PKM | |
| SCHEMBL2730327 | 0.80 | KMT2A (0.67) | KMT2AALDH1A1TSHRKCNJ1PKM | |
| SCHEMBL15825106 | 0.76 | KMT2A (0.71) | KMT2AKCNJ1LMNAMAPT | |
| SCHEMBL31191694 | 0.76 | NPC1 (0.58) | KMT2AALDH1A1TSHRNPC1PKM | |
| SCHEMBL12490951 | 0.76 | RAB9A (0.45) | KMT2AALDH1A1KCNJ1RAB9ALMNA | |
| SCHEMBL15018034 | 0.74 | KCNJ1 (0.49) | KMT2AALDH1A1TSHRKCNJ1HPGD | |
| SCHEMBL14243389 | 0.73 | KMT2A (0.58) | KMT2AALDH1A1TSHRPKMLMNA | |
| SCHEMBL15825107 | 0.73 | KCNJ1 (0.52) | KMT2AALDH1A1KCNJ1HPGDMAPT | |
| SCHEMBL1131457 | 0.73 | NOTUM (0.44) | KMT2AALDH1A1TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |