Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202768 | 1.00 | POLB (0.46) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL14144107 | 0.83 | POLB (0.45) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL6860723 | 0.83 | SMN1; SMN2 (0.45) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL27971973 | 0.83 | POLB (0.45) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL5250880 | 0.81 | POLB (0.44) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL2723323 | 0.81 | LMNA (0.44) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL6207733 | 0.81 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL1982237 | 0.81 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL3982504 | 0.81 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL2634067 | 0.81 | RAB9A (0.62) | LMNASMN1; SMN2L3MBTL1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632255-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058203-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |