Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202768 | 0.83 | POLB (0.46) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL2731646 | 0.83 | POLB (0.46) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL14144107 | 0.81 | POLB (0.45) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL27971973 | 0.81 | POLB (0.45) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL2634067 | 0.80 | RAB9A (0.62) | SMN1; SMN2LMNAL3MBTL1RAB9AALDH1A1 | |
| SCHEMBL6207733 | 0.80 | POLB (0.53) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL2723323 | 0.80 | LMNA (0.44) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL5250880 | 0.80 | POLB (0.44) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 | |
| SCHEMBL695608 | 0.80 | RAB9A (0.62) | SMN1; SMN2LMNAL3MBTL1RAB9AALDH1A1 | |
| SCHEMBL1982237 | 0.80 | POLB (0.53) | SMN1; SMN2LMNAPOLBL3MBTL1GBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790860-B2 | USEFUL AS INHIBITORS OF METALLOPROTEASES, E.G. ZINC PROTEASES; EFFECTIVE IN TREATING DISEASE STATES ASSOCIATED WITH VASOCONSTRICTION | HOFFMANN-LA ROCHE INC. | 2004-09-14 | — | — | US | disclosed |