SCHEMBL2731833

SCHEMBL2731833

COC(=O)c1ccc(-c2cc(I)c(OC)cc2F)nc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.40
NPC1 O15118 1/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
SOS1 Q07889 1/20 0.36
MAPT P10636 2/20 0.35
SDHB P21912 1/20 0.35
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
KDM4E B2RXH2 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ALPL P05186 1/20 0.34
TUBB4A P04350 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17364632 0.78 CFTR (0.43) CFTRNPC1SOS1MAPTKDM4E
SCHEMBL1529046 0.73 KDM4E (0.39) NPC1CASP3RAB9ASMN1; SMN2SENP8
SCHEMBL1529029 0.70 MAPT (0.46) RAB9AMAPTCYP1A2CYP2C9CYP2C19
SCHEMBL24986973 0.68 ALPL (0.40) SMN1; SMN2CD274KDM4EALPLALDH1A1
SCHEMBL10667889 0.68 TUBB4A (0.54) CFTRNPC1CASP3RAB9ASMN1; SMN2
SCHEMBL27702568 0.68 CFTR (0.46) CFTRNPC1CASP3RAB9ASMN1; SMN2
SCHEMBL5005835 0.68 NPC1 (0.54) CFTRNPC1CASP3RAB9ASMN1; SMN2
SCHEMBL4035807 0.67 KDM4E (0.46) SMN1; SMN2MAPTKDM4ECYP1A2CYP2D6
SCHEMBL28830749 0.67 XPO1 (0.55) CFTRNPC1CASP3RAB9ASMN1; SMN2
SCHEMBL30751960 0.67 XPO1 (0.55) CFTRNPC1CASP3RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2632269-A1 CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR Merck Sharp & Dohme Corp. (US) 2013-09-04 EP disclosed
WO-2012058187-A1 CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR MERCK SHARP & DOHME CORP. (US) 2012-05-03 WO disclosed