Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967776 | 0.79 | L3MBTL1 (0.59) | L3MBTL1POLBGAATDP1ATM | |
| SCHEMBL23644614 | 0.77 | ALDH1A1 (0.42) | L3MBTL1POLBITGB1ITGA4MEN1 | |
| SCHEMBL23644957 | 0.76 | PLA2G7 (0.43) | ITGB1ITGA4GAAKDM4EMEN1 | |
| SCHEMBL23644560 | 0.76 | MAPK1 (0.41) | L3MBTL1POLBTDP1MEN1KMT2A | |
| SCHEMBL23644167 | 0.74 | ITGB1 (0.39) | L3MBTL1POLBITGB1ITGA4GAA | |
| SCHEMBL23644970 | 0.73 | KDM4E (0.37) | L3MBTL1POLBITGB1ITGA4ATM | |
| SCHEMBL23644565 | 0.72 | ITGB1 (0.33) | ITGB1ITGA4CA1CA2 | |
| SCHEMBL23644161 | 0.71 | ITGB1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL23644138 | 0.71 | ITGB1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL18259718 | 0.70 | L3MBTL1 (0.51) | L3MBTL1POLBGAATDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046274-C | isoxazoline compounds as anti-inflammatory agents | PFIZER (US) | 1999-11-10 | — | — | CN | disclosed |
| CN-1143363-A | Isoxazoline compounds as inhibitors of TNF release | PFIZER (US) | 1997-02-19 | — | — | CN | disclosed |
| CN-1136314-A | Isoxazoline compounds as antiinflammatory agents | PFIZER (US) | 1996-11-20 | — | — | CN | disclosed |