Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.48 |
| ▸ | THRA | P10827 | 5/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545057 | 0.83 | KLK1 (0.47) | THRBTHRAKLK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27323262 | 0.80 | THRA (0.56) | THRBTHRASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11027108 | 0.78 | PPARG (0.40) | THRBTHRASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL26810030 | 0.78 | TPMT (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1334249 | 0.73 | L3MBTL1 (0.58) | THRBTHRASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7636855 | 0.73 | KMT2A (0.49) | THRBTHRAKLK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12370664 | 0.73 | KLK1 (0.44) | THRBTHRAKLK1ALDH1A1MEN1 | |
| SCHEMBL28031444 | 0.73 | HRH3 (0.40) | THRBTHRAKLK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8430188 | 0.72 | TSHR (0.66) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL31063303 | 0.71 | NCOA1 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1086387-C | N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, their preparation and their use as pharmaceuticals | HOECHST MARION ROUSSEL INC (US) | 2002-06-19 | — | — | CN | disclosed |
| CN-1048037-A | N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, their preparation and their use as pharmaceuticals | HOECHST ROUSSEL PHARMA (US) | 1990-12-26 | — | — | CN | disclosed |