Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732838 | 0.82 | MMP1 (0.46) | GAA | |
| SCHEMBL2732432 | 0.79 | KAT6A (0.46) | ALDH1A1GAAKMT2APOLB | |
| SCHEMBL2733097 | 0.78 | KAT6A (0.51) | MAPTALDH1A1GAAKMT2ALMNA | |
| SCHEMBL2733494 | 0.78 | GAA (0.46) | MAPTALDH1A1GAAKMT2ALMNA | |
| SCHEMBL2732088 | 0.77 | PKM (0.44) | PKMMAPTALDH1A1GAAPTPN1 | |
| SCHEMBL420216 | 0.76 | MAPT (0.45) | PKMMAPTALDH1A1GAAPTPN1 | |
| SCHEMBL2733302 | 0.75 | DAGLA (0.40) | PKMMAPTALDH1A1GAALMNA | |
| SCHEMBL10122126 | 0.74 | PKM (0.47) | PKMMAPTALDH1A1GAAPTPN1 | |
| SCHEMBL2732636 | 0.73 | KAT6A (0.37) | ALDH1A1GAAKMT2ALMNARAB9A | |
| SCHEMBL19938081 | 0.68 | MAPT (0.55) | PKMMAPTALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |