Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732432 | 0.84 | KAT6A (0.46) | KAT6ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2732838 | 0.83 | MMP1 (0.46) | KAT6AGAA | |
| SCHEMBL2733097 | 0.83 | KAT6A (0.51) | MAPTKAT6ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2733494 | 0.83 | GAA (0.46) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2732636 | 0.78 | KAT6A (0.37) | KAT6ALMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2733301 | 0.76 | MAPT (0.37) | DAGLAMAPTGFERKAT6ALMNA | |
| SCHEMBL2732090 | 0.75 | PKM (0.46) | MAPTLMNAPKMALDH1A1GAA | |
| SCHEMBL421293 | 0.74 | MAPT (0.46) | DAGLAPTGER4MAPTGFERKAT6A | |
| SCHEMBL2732878 | 0.72 | NR3C1 (0.44) | — | |
| SCHEMBL10122087 | 0.72 | GAA (0.43) | MAPTGFERKAT6ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | claimed |