Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18701477 | 0.75 | EGLN1 (0.46) | NOTUMKDM5B | |
| SCHEMBL18075726 | 0.70 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2TAAR1 | |
| SCHEMBL18075521 | 0.69 | MEN1 (0.37) | MEN1KMT2ASMN1; SMN2TAAR1 | |
| SCHEMBL11766361 | 0.67 | NOTUM (0.31) | NOTUM | |
| SCHEMBL7835747 | 0.66 | HSD17B10 (0.49) | MEN1KMT2ASMN1; SMN2TAAR1 | |
| SCHEMBL5451196 | 0.65 | HTR3A (0.51) | MEN1KMT2A | |
| SCHEMBL1129663 | 0.64 | HRH3 (0.44) | — | |
| SCHEMBL29774417 | 0.64 | RAB9A (0.35) | NOTUMKEAP1CYP19A1MEN1KMT2A | |
| SCHEMBL7018102 | 0.63 | BCHE (0.50) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL497431 | 0.63 | DCTPP1 (0.48) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629616-A2 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054366-A2 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-26 | — | — | WO | disclosed |