Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27322966 | 0.85 | KDM4E (0.52) | KDM4ETDP1ALDH1A1HPGDHIF1A | |
| SCHEMBL9381143 | 0.83 | KDM4E (0.53) | KDM4ETDP1ALDH1A1HPGDKMT2A | |
| SCHEMBL27310559 | 0.80 | KDM4E (0.53) | KDM4ETDP1ALDH1A1HPGDKMT2A | |
| SCHEMBL27344573 | 0.80 | KMT2A (0.47) | KDM4ETDP1ALDH1A1HPGDKMT2A | |
| SCHEMBL27325060 | 0.76 | TDP1 (0.52) | KDM4ETDP1ALDH1A1HPGDPTGDR2 | |
| SCHEMBL27309537 | 0.75 | TDP1 (0.51) | KDM4ETDP1PTGDR2MAPTTSHR | |
| SCHEMBL27310560 | 0.70 | PKM (0.49) | KDM4ETDP1ALDH1A1HPGDPTGDR2 | |
| SCHEMBL659122 | 0.68 | KDM4E (0.76) | KDM4ETDP1ALDH1A1HPGDKMT2A | |
| SCHEMBL692136 | 0.68 | KMT2A (0.65) | KDM4ETDP1ALDH1A1HPGDKMT2A | |
| SCHEMBL5538132 | 0.68 | KDM4E (0.51) | KDM4ETDP1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1027369-C | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | CN | disclosed |
| CN-1047292-A | EAA antagonists | MERRELL DOW PHARMA (US) | 1990-11-28 | — | — | CN | disclosed |