Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27309537 | 0.91 | TDP1 (0.51) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL9378776 | 0.82 | TDP1 (0.54) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL27310559 | 0.82 | KDM4E (0.53) | TDP1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL27310560 | 0.77 | PKM (0.49) | TDP1KDM4EPTGDR2PTGDRALDH1A1 | |
| SCHEMBL27344573 | 0.76 | KMT2A (0.47) | TDP1KDM4ETSHRPTGDR2ALDH1A1 | |
| SCHEMBL27322965 | 0.76 | KDM4E (0.52) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL9381607 | 0.73 | TDP1 (0.52) | TDP1KDM4EMAPTTSHRPTGDR2 | |
| SCHEMBL4720632 | 0.72 | HDAC1 (0.51) | KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL27627920 | 0.71 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1 | |
| SCHEMBL3025917 | 0.71 | KCNH2 (0.48) | KDM4ETSHRALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1027369-C | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | CN | disclosed |
| CN-1047292-A | EAA antagonists | MERRELL DOW PHARMA (US) | 1990-11-28 | — | — | CN | disclosed |